The story is set on an infected New York with Spider-Man once again faced with the challenge of ridding the City with the rampant spread of Venom symbiotes. New York City is completely quarantined by S.H.I.E.L.D. to prevent the symbiotes from infecting more civilians, rivals, and allies.
Here is the trailer for the Spider-Man Web of Shadows:
Here is Gametrailer's Review on the Game:
Spider-Man Web of Shadows